One of our Directors, David Heal, was Head of Biology at BASF Pharma, Nottingham, with global responsibility for obesity research (including projects investigating both central and peripheral pharmacological targets) and for preclinical studies to support the development and registration, positioning and marketing of the anti-obesity drug, sibutramine (Meridia/Reductil) in Europe, Japan, Australia, New Zealand, Canada and USA.
Over the past 20 years, our consultants have worked with many different companies on the discovery and development of novel drugs to treat obesity and type 2 diabetes.
Edited Books and Special Issues
Heal DJ, Smith SL, Jones RB. Special Issue of Neuropharmacology - “Central Regulation of Food Intake and Energy Expenditure”, 2012.
Antel J, Finer N, Heal D, Krause G. “Obesity and Metabolic Disorders”. Solvay Pharmaceuticals Conference Series, IOS Press, 2005.
Heal DJ, Gosden J, Jackson HC, Cheetham SC, Smith SL. Metabolic consequences of antipsychotic therapy: preclinical and clinical perspectives on diabetes, diabetic ketoacidosis, and obesity. Handbook Exp Pharmacol, 2012; 212: 135-164.
Lynch CJ, Zhou Q, Shyng SL, Heal DJ, Cheetham SC, Dickinson K, Gregory P, Firnges M, Nordheim U, Goshorn S, Reiche D, Turski L, Antel J. Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels. Am J Physiol Endocrinol Metab, 2012; 302: E540-E551.
Heal DJ, Smith SL, Fisas A, Codony X, Buschmann H. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacol Ther, 2008; 117: 207-231.
Heal DJ. Obesity drug development - CBI's 2nd Annual Summit. Drugs, 2006; 9: 682-685.
Cheetham SC, Jackson HC, Vickers SP, Dickinson K, Jones RB, Heal DJ. Novel targets for the treatment of obesity: a review of progress. Drug Disc Today, 2004; 1: 227-235.
Heal DJ, Rowley HL, Jackson HC. Delivering the next generation of anti-obesity therapies – challenges for pharmacogenomics, patients and the pharmaceutical industry. In: Progress in Obesity Research, Volume 9. Medeiros-Nero G, Halpern A, Bouchard C (Eds). pp 260-264. John Libbey, Paris, 2003.
Heal DJ, Aspley S, Prow MR, Jackson HC, Martin KF, Cheetham SC. Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine. Int J Obes Relat Metab Disord, 1998; 22 (Suppl 1): S18-S28; discussion S29.
Heal DJ, Vickers SP, Hackett D, Hutson PH. Metabolic effects of lisdexamfetamine in a rat model of human obesity with insulin resistance. European College of Neuropsychopharmacology, Oct 2013.
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