Binge-eating disorder (BED) is a common psychiatric condition with adverse psychological and metabolic consequences. Our consultants supported the development of lisdexamfetamine (Vyvanse®), the first drug marketed for the management of moderate to severe binge-eating disorder in adults.
We have devised and validated new animal models of binge-eating disorder, models of impulsivity (delay-discounting tasks) and compulsive and perseverative behaviour in binge-eating rats.
Our research papers and reviews on the pharmacological interventions effective in BED and future prospects for drug discovery and development in this indication are given below.
Heal DJ, Gosden J. What pharmacological interventions are effective in binge-eating disorder? Insights from a critical evaluation of the evidence from clinical trials. Int J Obes, 2022; 46: 677–695. doi: 10.1038/s41366-021-01032-9. Epub 2022 Jan 7.
Heal DJ, Smith SL. Prospects for new drugs to treat binge-eating disorder: Insights from psychopathology and neuropharmacology. J Psychopharmacol, 2022; 36(6): 680-703. doi: 10.1177/02698811211032475. Epub 2021 Jul 28.
Heal DJ, Hallam M, Prow M, Gosden J, Cheetham S, Choi YK, Tarazi F, Hutson P. Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats - possible relevance in the psychopathology and treatment of binge-eating disorder. J Psychopharmacol, 2017; 31: 770-783.
Vickers SP, Goddard S, Brammer RJ, Hutson PH, Heal DJ. Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine. J Psychopharmacol, 2017; 31: 784-797.
Heal DJ, Goddard S, Brammer RJ, Hutson PH, Vickers SP. Lisdexamfetamine reduces the compulsive and perseverative behaviour of binge-eating rats in a novel food reward/punished responding conflict model. J Psychopharmacol, 2016; 30: 662-675.
Heal DJ, Vickers SP, Hopkins SC, Koblan KS. Investigation of the effects of dasotraline in a validated rat model of binge-eating disorder. American College of Neuropsychopharmacology Meeting, Dec 2018.
Hutson PH, Vickers SP, Goddard S, Hallam M, Brammer RJ, Heal DJ. Preclinical evidence to demonstrate that lisdexamfetamine prevents impulsivity in binge-eating. American College of Neuropsychopharmacology Meeting, Dec 2015.
Tarazi FI, Choi YK, Gosden J, Heal DJ, Hutson PH. Reduced expression of GAD65/67 mRNA and dopamine D1 and D2 receptors in binge-eating rats. American College of Neuropsychopharmacology Meeting, Dec 2015.
Heal DJ, Hutson PH, Goddard S, Brammer RJ, Vickers SP. Binge-eating rats exhibit compulsive and perseverative behaviour in a novel food reward/punished responding model. Society for Neurosciences Congress, Oct 2015.
Vickers SP, Hutson PH, Goddard S, Hallam M, Brammer RJ, Heal DJ. Binge-eating rats show marked impulsivity in a delay discounting test. Society for Neurosciences Congress, Oct 2015.
Hutson P, Rowley HL Kulkarni RS, Heal DJ. Lisdexamfetamine-induced suppression of binge eating in rats is attenuated by the α1 adrenoceptor antagonist, prazosin. American College of Neuropsychopharmacology Meeting, Dec 2014.
Heal DJ, Vickers SP, Hackett D, Hutson PH. Effect of lisdexamfetamine in a rat model of binge-eating disorder. European College of Neuropsychopharmacology, Oct 2013.
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